| Autor: |
Li, Dong, Brown, James B., Orsini, Luisa, Pan, Zhisong, Hu, Guyu, He, Shan |
| Rok vydání: |
2016 |
| Předmět: |
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| Druh dokumentu: |
Working Paper |
| Popis: |
Gene co-expression network differential analysis is designed to help biologists understand gene expression patterns under different condition. By comparing different gene co-expression networks we may find conserved part as well as condition specific set of genes. Taking the network as a collection as modules, we use a sample-saving method to construct condition-specific gene co-expression network, and identify differentially expressed subnetworks as conserved or condition specific modules which may be associated with biological processes. We have implemented the method as an R package which establishes a pipeline from expression profile to biological explanations. The usefulness of the method is also demonstrated by synthetic data as well as Daphnia magna gene expression data under different environmental stresses. |
| Databáze: |
arXiv |
| Externí odkaz: |
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