| Autor: |
Kakatkar, Aniket, Abhilash, T. S., De Alba, Roberto, Parpia, Jeevak M, Craighead, Harold G |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Nanotechnology 26, 125502 (2015) |
| Druh dokumentu: |
Working Paper |
| DOI: |
10.1088/0957-4484/26/12/125502 |
| Popis: |
A graphene channel field-effect biosensor is demonstrated for detecting the binding of double-stranded DNA and poly-l-lysine. Sensors consist of CVD graphene transferred using a clean, etchant-free transfer method. The presence of DNA and poly-l-lysine are detected by the conductance change of the graphene transistor. A readily measured shift in the Dirac Voltage (the voltage at which the graphenes resistance peaks) is observed after the graphene channel is exposed to solutions containing DNA or poly-l-lysine. The Dirac voltage shift is attributed to the binding/unbinding of charged molecules on the graphene surface. The polarity of the response changes to positive direction with poly-l-lysine and negative direction with DNA. This response results in detection limits of 8 pM for 48.5 kbp DNA and 11 pM for poly-l-lysine. The biosensors are easy to fabricate, reusable and are promising as sensors of a wide variety of charged biomolecules |
| Databáze: |
arXiv |
| Externí odkaz: |
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