Characterization of DNA methylation as a function of biological complexity via dinucleotide inter-distances

Autor:	Paci, Giulia, Cristadoro, Giampaolo, Monti, Barbara, Lenci, Marco, Esposti, Mirko Degli, Castellani, Gastone C., Remondini, Daniel
Rok vydání:	2015
Předmět:	Quantitative Biology - Quantitative Methods Physics - Biological Physics Quantitative Biology - Genomics Statistics - Applications
Druh dokumentu:	Working Paper
DOI:	10.1098/rsta.2015.0227
Popis:	We perform a statistical study of the distances between successive occurrencies of a given dinucleotide in the DNA sequence for a number of organisms of different complexity. Our analysis highlights peculiar features of the dinucleotide CG distribution in mammalian DNA, pointing towards a connection with the role of such dinucleotide in DNA methylation. While the CG distributions of mammals exhibit exponential tails with comparable parameters, the picture for the other organisms studied (e.g., fish, insects, bacteria and viruses) is more heterogeneous, possibly because in these organisms DNA methylation has different functional roles. Our analysis suggests that the distribution of the distances between dinucleotides CG provides useful insights in characterizing and classifying organisms in terms of methylation functionalities. Comment: 13 pages, 5 figures. To be published in the Philosophical Transactions A theme issue "DNA as information"
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1511.08445 Zobrazit plný text záznamu View this record from Arxiv