M\'as all\'a del GWAS: alternativas para localizar QTLs

Autor:	Biscarini, Filippo, Biffani, Stefano, Stella, Alessandra
Jazyk:	Spanish; Castilian
Rok vydání:	2015
Předmět:	Quantitative Biology - Genomics
Druh dokumentu:	Working Paper
Popis:	Beyond GWAS: alternatives to localize QTLs in farm animals. Two methods that could be used for QTL mapping as alternatives to standard GWAS are presented. The first relies on the differential frequency of runs of homozygosity (ROH) in groups of animals (e.g. cases and controls), while the second stems from resampling techniques used for the prediction of carriers of a mutation, and is based on the frequency of inclusion of polymorphisms (SNP) in the predictive model. ROH were applied to the detection of reproductive diseases in Holstein-Friesian cattle, while resampling was applied to the detection of carriers of the BH2 haplotype in Brown Swiss cattle. These alternative approaches may complement GWAS analyses in localizing more accurately QTLs for traits of interest in livestock. Comment: 5 pages, 3 figures, article in Spanish with abstract both in Spanish and English
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1504.03802 Zobrazit plný text záznamu View this record from Arxiv