Structuring research methods and data with the Research Object model: genomics workflows as a case study
| Autor: | Hettne, Kristina M., Dharuri, Harish, Zhao, Jun, Wolstencroft, Katherine, Belhajjame, Khalid, Soiland-Reyes, Stian, Mina, Eleni, Thompson, Mark, Cruickshank, Don, Verdes-Montenegro, Lourdes, Garrido, Julian, de Roure, David, Corcho, Oscar, Klyne, Graham, van Schouwen, Reinout, Hoen, Peter A. C. 't, Bechhofer, Sean, Goble, Carole, Roos, Marco |
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| Rok vydání: | 2013 |
| Předmět: | |
| Druh dokumentu: | Working Paper |
| DOI: | 10.1186/2041-1480-5-41 |
| Popis: | One of the main challenges for biomedical research lies in the computer-assisted integrative study of large and increasingly complex combinations of data in order to understand molecular mechanisms. The preservation of the materials and methods of such computational experiments with clear annotations is essential for understanding an experiment, and this is increasingly recognized in the bioinformatics community. Our assumption is that offering means of digital, structured aggregation and annotation of the objects of an experiment will provide necessary meta-data for a scientist to understand and recreate the results of an experiment. To support this we explored a model for the semantic description of a workflow-centric Research Object (RO), where an RO is defined as a resource that aggregates other resources, e.g., datasets, software, spreadsheets, text, etc. We applied this model to a case study where we analysed human metabolite variation by workflows. Comment: 35 pages, 10 figures, 1 table. Submitted to Journal of Biomedical Semantics on 2013-05-13, resubmitted after reviews 2013-11-09, 2014-06-27. Accepted in principle 2014-07-29. Published: 2014-09-18 http://www.jbiomedsem.com/content/5/1/41. Research Object homepage: http://www.researchobject.org/ |
| Databáze: | arXiv |
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