An ensemble approach to the study of the emergence of metabolic and proliferative disorders via Flux Balance Analysis

Autor:	Damiani, Chiara, Colombo, Riccardo, Molinari, Sara, Pescini, Dario, Gaglio, Daniela, Vanoni, Marco, Alberghina, Lilia, Mauri, Giancarlo
Rok vydání:	2013
Předmět:	Computer Science - Computational Engineering Finance and Science Quantitative Biology - Molecular Networks
Zdroj:	EPTCS 130, 2013, pp. 92-97
Druh dokumentu:	Working Paper
DOI:	10.4204/EPTCS.130.15
Popis:	An extensive rewiring of cell metabolism supports enhanced proliferation in cancer cells. We propose a systems level approach to describe this phenomenon based on Flux Balance Analysis (FBA). The approach does not explicit a cell biomass formation reaction to be maximized, but takes into account an ensemble of alternative flux distributions that match the cancer metabolic rewiring (CMR) phenotype description. The underlying concept is that the analysis the common/distinguishing properties of the ensemble can provide indications on how CMR is achieved and sustained and thus on how it can be controlled. Comment: In Proceedings Wivace 2013, arXiv:1309.7122
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1309.7696 Zobrazit plný text záznamu View this record from Arxiv