Enhanced Tumor Accumulation of Sub-2 nm Gold Nanoclusters for Cancer Radiation Therapy

Autor:	Zhang, Xiao-Dong, Chen, Jie, Luo, Zhentao, Wu, Di, Shen, Xiu, Song, Sha-Sha, Sun, Yuan-Ming, Liu, Pei-Xun, Zhao, Jing, Huo, Shuaidong, Fan, Saijun, Fan, Feiyue, Liang, Xing-Jie, Xie, Jianping
Rok vydání:	2013
Předmět:	Physics - Biological Physics Physics - Medical Physics
Druh dokumentu:	Working Paper
DOI:	10.1002/adhm.201300189
Popis:	A new type of metabolizable and efficient radiosensitizer for cancer radiotherapy is presented in this study by combining ultrasmall Au nanoclusters (NCs, <2 nm) with biocompatible coating ligands (glutathione, GSH). The new nano-construct (GSH-coated Au25 NCs) inherits attractive features of both the Au core (strong radiosensitizing effect) and GSH shell (good biocompatibility). It can preferentially accumulate in tumor via the improved EPR effect, which leads to strong enhancement for cancer radiotherapy. After the treatment, the small-sized GSH-Au25 NCs can be efficiently cleared by the kidney, minimizing any potential side effects due to the accumulation of Au25 NCs in the body. Comment: 27 pages,10 figures Advanced Healthcare Materials(2014)
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1308.6737 Zobrazit plný text záznamu View this record from Arxiv