Towards dynamical network biomarkers in neuromodulation of episodic migraine

Autor:	Dahlem, Markus A., Rode, Sebastian, May, Arne, Fujiwara, Naoya, Hirata, Yoshito, Aihara, Kazuyuki, Kurths, Jürgen
Rok vydání:	2013
Předmět:	Quantitative Biology - Neurons and Cognition Nonlinear Sciences - Pattern Formation and Solitons
Druh dokumentu:	Working Paper
DOI:	10.2478/s13380-013-0127-0
Popis:	Computational methods have complemented experimental and clinical neursciences and led to improvements in our understanding of the nervous systems in health and disease. In parallel, neuromodulation in form of electric and magnetic stimulation is gaining increasing acceptance in chronic and intractable diseases. In this paper, we firstly explore the relevant state of the art in fusion of both developments towards translational computational neuroscience. Then, we propose a strategy to employ the new theoretical concept of dynamical network biomarkers (DNB) in episodic manifestations of chronic disorders. In particular, as a first example, we introduce the use of computational models in migraine and illustrate on the basis of this example the potential of DNB as early-warning signals for neuromodulation in episodic migraine. Comment: 13 pages, 5 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1308.3552 Zobrazit plný text záznamu View this record from Arxiv