Some Notes on Blinded Sample Size Re-Estimation
Autor: | Glimm, Ekkehard, Läuter, Jürgen |
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Rok vydání: | 2013 |
Předmět: | |
Druh dokumentu: | Working Paper |
Popis: | This note investigates a number of scenarios in which unadjusted testing following a blinded sample size re-estimation leads to type I error violations. For superiority testing, this occurs in certain small-sample borderline cases. We discuss a number of alternative approaches that keep the type I error rate. The paper also gives a reason why the type I error inflation in the superiority context might have been missed in previous publications and investigates why it is more marked in case of non-inferiority testing. Comment: 19 pages, 1 figure |
Databáze: | arXiv |
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