Some Notes on Blinded Sample Size Re-Estimation

Autor: Glimm, Ekkehard, Läuter, Jürgen
Rok vydání: 2013
Předmět:
Druh dokumentu: Working Paper
Popis: This note investigates a number of scenarios in which unadjusted testing following a blinded sample size re-estimation leads to type I error violations. For superiority testing, this occurs in certain small-sample borderline cases. We discuss a number of alternative approaches that keep the type I error rate. The paper also gives a reason why the type I error inflation in the superiority context might have been missed in previous publications and investigates why it is more marked in case of non-inferiority testing.
Comment: 19 pages, 1 figure
Databáze: arXiv