Achieving Control of Lesion Growth in CNS with Minimal Damage

Autor:	Raja, Mathankumar, Mohan, T. R. Krishna
Rok vydání:	2012
Předmět:	Nonlinear Sciences - Adaptation and Self-Organizing Systems Physics - Biological Physics Quantitative Biology - Cell Behavior Quantitative Biology - Neurons and Cognition
Druh dokumentu:	Working Paper
Popis:	Lesions in central nervous system (CNS) and their growth leads to debilitating diseases like Multiple Sclerosis (MS), Alzheimer's etc. We developed a model earlier which shows how the lesion growth can be arrested through a beneficial auto-immune mechanism. The success of the approach depends on a set of control parameters and their phase space was shown to have a smooth manifold separating the uncontrolled lesion growth region from the controlled. Here we show that an optimal set of parameter values exist which minimizes system damage while achieving control of lesion growth.
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1209.0257 Zobrazit plný text záznamu View this record from Arxiv