Extremely rare interbreeding events can explain Neanderthal DNA in modern humans
| Autor: | Neves, Armando G. M., Serva, Maurizio |
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| Rok vydání: | 2011 |
| Předmět: | |
| Druh dokumentu: | Working Paper |
| Popis: | Considering the recent experimental discovery of Green et al that present day non-Africans have 1 to 4% of their nuclear DNA of Neanderthal origin, we propose here a model which is able to quantify the interbreeding events between Africans and Neanderthals at the time they coexisted in the Middle East. The model consists of a solvable system of deterministic ordinary differential equations containing as a stochastic ingredient a realization of the neutral Wright-Fisher drift process. By simulating the stochastic part of the model we are able to apply it to the interbreeding of African and Neanderthal subpopulations and estimate the only parameter of the model, which is the number of individuals per generation exchanged between subpopulations. Our results indicate that the amount of Neanderthal DNA in non-Africans can be explained with maximum probability by the exchange of a single pair of individuals between the subpopulations at each 77 generations, but larger exchange frequencies are also allowed with sizeable probability. The results are compatible with a total interbreeding population of order 10,000 individuals and with all living humans being descendents of Africans both for mitochondrial DNA and Y chromosome. Comment: 26 pages, 6 figures, updated version |
| Databáze: | arXiv |
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