A population-based microbial oscillator

Autor:	Goni-Moreno, Angel, Amos, Martyn
Rok vydání:	2010
Předmět:	Quantitative Biology - Cell Behavior Nonlinear Sciences - Adaptation and Self-Organizing Systems
Druh dokumentu:	Working Paper
Popis:	Genetic oscillators are a major theme of interest in the emerging field of synthetic biology. Until recently, most work has been carried out using intra-cellular oscillators, but this approach restricts the broader applicability of such systems. Motivated by a desire to develop large-scale, spatially-distributed cell-based computational systems, we present an initial design for a population-level oscillator which uses three different bacterial strains. Our system is based on the client-server model familiar to computer science, and uses quorum sensing for communication between nodes. We present the results of extensive in silico simulation tests, which confirm that our design is both feasible and robust. Comment: Submitted
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1007.4583 Zobrazit plný text záznamu View this record from Arxiv