Monitoring Ion Channel Function In Real Time Through Quantum Decoherence
| Autor: | Hall, L. T., Hill, C. D., Cole, J. H., Städler, B., Caruso, F., Mulvaney, P., Wrachtrup, J., Hollenberg, L. C. L. |
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| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | PNAS, published ahead of print October 11, 2010 |
| Druh dokumentu: | Working Paper |
| DOI: | 10.1073/pnas.1002562107 |
| Popis: | In drug discovery research there is a clear and urgent need for non-invasive detection of cell membrane ion channel operation with wide-field capability. Existing techniques are generally invasive, require specialized nano structures, or are only applicable to certain ion channel species. We show that quantum nanotechnology has enormous potential to provide a novel solution to this problem. The nitrogen-vacancy (NV) centre in nano-diamond is currently of great interest as a novel single atom quantum probe for nanoscale processes. However, until now, beyond the use of diamond nanocrystals as fluorescence markers, nothing was known about the quantum behaviour of a NV probe in the complex room temperature extra-cellular environment. For the first time we explore in detail the quantum dynamics of a NV probe in proximity to the ion channel, lipid bilayer and surrounding aqueous environment. Our theoretical results indicate that real-time detection of ion channel operation at millisecond resolution is possible by directly monitoring the quantum decoherence of the NV probe. With the potential to scan and scale-up to an array-based system this conclusion may have wide ranging implications for nanoscale biology and drug discovery. Comment: 7 pages, 6 figures |
| Databáze: | arXiv |
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