The self-assembly and evolution of homomeric protein complexes

Autor:	Villar, Gabriel, Wilber, Alex W., Williamson, Alex J., Thiara, Parvinder, Doye, Jonathan P. K., Louis, Ard A., Jochum, Mara N., Lewis, Anna C. F., Levy, Emmanuel D.
Rok vydání:	2008
Předmět:	Quantitative Biology - Biomolecules
Zdroj:	Phys. Rev. Lett. 102, 118106 (2009)
Druh dokumentu:	Working Paper
DOI:	10.1103/PhysRevLett.102.118106
Popis:	We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes involving the stronger interactions are observed to be thermodynamically stable on destabilization of the protein-protein interactions and (iii) the self-assembly dynamics are hierarchical with these same subcomplexes acting as kinetic intermediates. Comment: 4 pages, 4 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/0811.3716 Zobrazit plný text záznamu View this record from Arxiv