Complex patterns of spontaneous initiations and terminations of reentrant circulation in a loop of cardiac tissue
| Autor: | Sedaghat, H., Wood, M. A., Cain, J. W., Cheng, C-K., Baumgarten, C. M., Chan, D. M. |
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| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Journal of Theoretical Biology, 254 (2008) 14-26 |
| Druh dokumentu: | Working Paper |
| DOI: | 10.1016/j.jtbi.2008.05.003 |
| Popis: | A two-component model is developed that consists of a discrete loop of cardiac cells that circulates action potentials together with a cardiac pacing mechanism. Physiological properties of cells such as restitutions of refractoriness and of conduction velocity are given via experimentally measured functions. The dynamics of circulating pulses and their interactions with the pacer are regulated by two threshold relations. Patterns of spontaneous initiations and terminations of reentry (SITR) generated by this system are studied through numerical simulations and analytical observations. These patterns can be regular or irregular; causes of irregularities are identified as the threshold bistability of reentrant circulation (T-bistability) and in some cases, also phase-resetting interactions with the pacer. Comment: 27 pages, 10 figures, 61 references; A version of this paper (same results) is to appear in the Journal of Theoretical Biology; arXiv V2 adds helpful commments to facilitate reading and corrects minor errors in presentation |
| Databáze: | arXiv |
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