Optimized free energies from bidirectional single-molecule force spectroscopy
| Autor: | Minh, David D. L., Adib, Artur B. |
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| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Phys. Rev. Lett. 100, 180602 (2008) |
| Druh dokumentu: | Working Paper |
| DOI: | 10.1103/PhysRevLett.100.180602 |
| Popis: | An optimized method for estimating path-ensemble averages using data from processes driven in opposite directions is presented. Based on this estimator, bidirectional expressions for reconstructing free energies and potentials of mean force from single-molecule force spectroscopy - valid for biasing potentials of arbitrary stiffness - are developed. Numerical simulations on a model potential indicate that these methods perform better than unidirectional strategies. Comment: 4 pages, 2 figures |
| Databáze: | arXiv |
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