Mechanical response of plectonemic DNA: an analytical solution

Autor:	Clauvelin, N., Audoly, B., Neukirch, S.
Rok vydání:	2008
Předmět:	Quantitative Biology - Biomolecules
Druh dokumentu:	Working Paper
DOI:	10.1021/ma702713x
Popis:	We consider an elastic rod model for twisted DNA in the plectonemic regime. The molecule is treated as an impenetrable tube with an effective, adjustable radius. The model is solved analytically and we derive formulas for the contact pressure, twisting moment and geometrical parameters of the supercoiled region. We apply our model to magnetic tweezer experiments of a DNA molecule subjected to a tensile force and a torque, and extract mechanical and geometrical quantities from the linear part of the experimental response curve. These reconstructed values are derived in a self-contained manner, and are found to be consistent with those available in the literature. Comment: 14 pages, 4 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/0801.3344 Zobrazit plný text záznamu View this record from Arxiv