İlaç Hammaddesi Olarak Sentezlenen Elektrofilik ve Nonelektrofilik Fenolik Schiff Bazlarının Umu Test Sistemi ile Genotoksik Aktivitesinin Araştırılması
| Autor: | CEYHAN, Emre, MERCANGÖZ, Ayşe, KARAKOÇ, Nimet, BİLGİÇ, Sevim |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Volume: 7, Issue: 2 Cankaya University Journal of Science and Engineering |
| ISSN: | 2564-7954 |
| Popis: | In this work, we investigated, through a short-term genotoxicity experiment,the umu-test, the mutagenic activities of a group of phenolic Schiff bases, namely MaterialA 2-(N-phenyliminomethyl)-phenol, Material B 2-(N-p-bromophenyliminomethyl)-phenol, Material C 2-(N-p-methylphenyliminomethyl)-phenol and Material D 2-(N-panilinephenyliminomethyl)-phenol, the substances which we synthesized, in the chemistrylaboratories of our university, to form the raw materials of medicines. The umu-testmethod is a colorimetric bacterial test system and has been developed on the basis of SOSresponse induced by DNA damage. Materials A, B, C and D and the experimental materialsprepared in 5 different dose levels by dissolving these materials in DMSO have notincreased the galactosidase enzyme activity. When calculated with respect to the enzymeunit calculation formula, results seemed to be not larger than the unit value of the positivemutagenic material 4NQO. Results have also been evaluated statistically. |
| Databáze: | OpenAIRE |
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