Biological Agent Use in Behçet's Patients Who Are Resistant to Conventional Treatments: A Multidisciplinary Retrospective Study
| Autor: | YAĞIZ, Burcu, COŞKUN, Belkıs Nihan, ÇAKAN, Zeliha Kübra, UÇAN GÜNDÜZ, Gamze, YALÇINBAYIR, Özgür, YAZİCİ, Serkan, SARICAOĞLU, Hayriye, DALKILIÇ, Hüseyin Ediz, PEHLİVAN, Yavuz |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Volume: 5, Issue: 1 33-40 Turkish Journal of Internal Medicine |
| ISSN: | 2687-4245 |
| Popis: | Background Comparing treatment modalities is difficult in Behcet's syndrome, even if tumour necrosis factor-alpha (TNF-α) inhibitors are a treatment option for all involvements resistant to conventional therapy. This study evaluated how different departments dealt with treatment, particularly with TNF-α inhibitors.Material and Methods The study comprised 111 patients from our Behcet's syndrome cohort who were treated with TNF-α inhibitors between 2010 and 2019. Data on patients were retrieved retrospectively from the rheumatology, ophthalmology, and dermatology clinics' patient records. Results Patients followed up in rheumatology (n: 40) were classified as Group 1, and patients followed up in ophthalmology (n: 49) and dermatology (n: 5) as Group 2. In Group 1, genital ulcers, erythema nodosum (p=0.009, p=0.003, respectively), lower extremity deep vein thrombosis, arterial aneurysm and neurological involvement were more common (p=0.005, p=0.008, p=0.001, respectively). In Group 2, the use of cyclosporine and interferon-α before the anti-TNF agent was higher (p |
| Databáze: | OpenAIRE |
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