Oxidative stress level in patients with chronic kidney disease
| Autor: | ATEŞ, İhsan, Özkayar, Nihal, Yılmaz, Fatma Meriç, Bayrakçı, Nergiz, Neselioğlu, Salim, Erel, Özcan, Coşkun yenigün, Ezgi, Dede, Fatih |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Volume: 10, Issue: 1 45-50 Ortadoğu Tıp Dergisi |
| ISSN: | 2548-0251 |
| Popis: | Amaç: Bu çalışmada kronik böbrek hastalığı olan hastalardadinamik tiyol/disülfid dengesinin araştırılması amaçlandı.Gereçve Yöntem: Çalışmaya evre 1-5 (non diyaliz)150 (57 erkek, 93 kadın) kronik böbrekhastası ve (76 (30 erkek, 46 kadın) sağlıklıkontrol grubu alındı. Kan tiyol/disülfid dengesi yeni geliştirilen otomatik vekalorimetrik bir yöntemle ölçüldü. Bulgular: Tümpopülasyonun serum thiol düzeyi ortalaması 320.8±57.8 µmol/L, totalthiol düzeyi ortalaması 352.0±61.5 µmol/L, ortalama disülfid düzeyi 15.6±5.3 µmol/L idi.Kronik böbrek hastalarında ortalama serum thiol (p Background: In this study, we aimed to evaluate the presence ofoxidative stress in chronic kidney disease (CKD) by measuring dynamic thiol/disulphide homeostasis.Material and Method: Ahundred fifty patients (57 men, 93 women) followed with a diagnosis of CKD(stages 1-5, not on dialysis) and 76 healthy, disease-free individuals (30 men,46 women) were included in the study. Blood thiol/disulphide homeostasis wasmeasured by newly developed automatic and colorimetric method by Erel and Neselioglu.Results: The mean serum native thiol (p =0.001), total thiol (p = 0.001) and disulphide (p =0.041) levels were lower in CKD than in the control group. No significantdifference was found between the CKD and control groups in terms of disulphide/thiol, disulphide/totalthiol and thiol/total thiol ratios (p >0.05). Serum native thiol and total thiol levelswere correlated negatively with both BMI and serum phosphorous level while boththe parameters were correlated positively with glomerular filtration rate,total protein level and albumin level. A negative correlation was found betweentotal thiol and age. Disulphidelevels were correlated positively with albumin and total protein and negativelywith uric acid levels. Conclusion: Our study shows that low serum thiollevels in CKD is due to a decrease in total thiol reserve of the body and notdue to conversion of thiol groups into disulphides. |
| Databáze: | OpenAIRE |
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