Synthesis and Antimicrobial Activity of Some 3(2H)-Pyridazinone and 1(2H)-Phthalazinone Derivatives

Autor:	DOĞRUER, Deniz S., ÖNKOL, Tijen, ÖZKAN, Semiha, ÖZGEN, Selda, ŞAHİN, M. Fethi
Jazyk:	turečtina
Rok vydání:	2014
Předmět:	3(2H)-pyridazinone 1(2H)-phthalazinone antimicrobial activity
Zdroj:	Volume: 32, Issue: 4 469-479 Turkish Journal of Chemistry
ISSN:	1300-0527 1303-6130
Popis:	Some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives were synthesized. The structures of these new compounds were confirmed by IR, 1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds were evaluated for their antibacterial activity against various gram-positive and gram-negative strains of bacteria and their clinical isolates and for their antimycobacterial activity against M. tuberculosis H37Rv. The results showed that the synthesized compounds were generally active against B. subtilis and its clinical isolate. Among the target compounds, compound 14c exhibited the best antibacterial activity, with a MIC value of 15.62 m g/mL against B. subtilis. Compound 15e had the highest antimycobacterial activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=tubitakulakb::d3042d052fe7386084931ca7299f9195 https://dergipark.org.tr/tr/pub/tbtkchem/issue/11909/142385 Zobrazit plný text záznamu