Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

Autor:	DOĞRUER, Deniz S., URLU, Şölen, ÖNKOL, Tijen
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Engineering Mühendislik Pyridazine derivatives antibacterial activity antifungal activity
Zdroj:	Volume: 34, Issue: 1 57-65 Turkish Journal of Chemistry
ISSN:	1300-0527 1303-6130
Popis:	Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by 1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 m g/mL) and E. coli (MIC ranging from 4 to 16 m g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 m g/mL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=tubitakulakb::baafe8255b7a8ec195ff7a72cf0e0f79 https://dergipark.org.tr/tr/pub/tbtkchem/issue/11900/142260 Zobrazit plný text záznamu