Microwave assisted synthesis of ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4- dihydro-2H-furo[3,2-c]chromene-3-carboxylate via manganese(III) acetate mediated radical cyclization reaction

Autor:	KHEZRİ, Negar, BURGAZ, E. Vildan
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Kimya Organik Radical Cyclization Reaction Manganese (III) Acetate Dihydrofuran Microwave irradiation Chemistry Organic
Zdroj:	Volume: 3, Issue: 2 80-85 EMU Journal of Pharmaceutical Sciences
ISSN:	2651-3587
Popis:	“Ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4-dihydro-2H-furo[3,2-c]chromene-3-carboxylate” is dihydro- furan-fused monocyclic heterocycles containing dihydrofurocoumarin framework. Compounds that include these core structures are especially important for drug discovery. Manganese(III) acetate has been used as an efficient oxidizing agent for the preparation of “ethyl 2,2-bis(4-fluorophenyl)-4-oxo-3,4-dihydro-2H-furo[3,2-c]chromene-3-carboxylate” by the multi-steps reaction of ethyl 3,3-bis(4-fluorophenyl)acrylate and 4-hydroxycoumarin under microwave irradiation to perform faster heating times, significantly reduce reaction times, and the efficient solubilization of manganese(III) acetate in acetic acid. The cyclization reaction was achieved using reactivity of the carbonyl group within the molecule.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=tubitakulakb::b2dfd87300b2a40987742fb050f28f54 https://dergipark.org.tr/tr/pub/emujpharmsci/issue/57718/776466 Zobrazit plný text záznamu