Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite
| Autor: | AĞALAR, Hale Gamze, İŞCAN, Gökalp, NOMA, Yoshiaki, ATLI, Özlem, DEMİRCİ, Fatih, KIRIMER, Neşe |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Volume: 4, Issue: 1 14-17 Natural Volatiles and Essential Oils |
| ISSN: | 2148-9637 |
| Popis: | The substrate of this study, 2,5-dimethyl-1,4-benzoquinone (DMBQ), is one of the naturally occurring quinones which is found ininsects as a defence metabolite. In the present study, DMBQ was biotransformed by using the micro-fungus Corynespora cassicola.The transformation metabolite was initially screened by TLC and GC-MS, then further characterized by NMR (13C- and 1H-NMR)spectroscopic techniques and was identified as ‘2,5-dimethyl 1,4-benzenediol’. In addition, both the substrate and metabolite wasevaluated for the in vitro anticandidal, and antioxidant properties along with XTT-cytotoxicity. |
| Databáze: | OpenAIRE |
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