The Assestment of The Course of Disease in Patients with Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatıc Arthritis in whom the Remisson had been Maintained by Anti-TNF-α Medication and then Medication had been Ceased
| Autor: | KUTLU, Nagehan Dik, COŞKUN, Belkıs Nihan, TUFAN, Ayşe Nur, ÖKSÜZ, Mustafa Ferhat, ERMURAT, Selime, ÖZKAYA, Güven, PEHLİVAN, Yavuz, DALKILIÇ, Ediz |
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| Jazyk: | turečtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Volume: 42, Issue: 2, 3 61-65 Uludağ Üniversitesi Tıp Fakültesi Dergisi |
| ISSN: | 1300-414X 2645-9027 |
| Popis: | TNF-α inhibitör (TNFi) tedavisi ile remisyon elde edilmiş, tedaviye ara verilmiş inflamatuar romatolojik hastalık (İRH) tanılı bireylerin seyrini ortaya koymayı amaçladık. Hastalar geriye dönük olarak incelendi. C-reaktif protein (CRP), eritrosit sedimantasyon hızı (ESR) yanı sıra hastalık aktivite ölçütleri göz önünde bulunduruldu. Çalışmamıza 64 İRH (22 Romatoid Artrit (RA), 37 Ankilozan Spondilit (AS), 5 Psöriatik Artrit (PsA)) tanılı hasta dahil edildi. TNFi kesilmesiyle toplam 58 hastada reaktivasyon gelişmişti. Reaktivasyona kadar geçen süre ortalama 6 aydı. Hastaların 28’ inde (%46) ilk 6 ay içinde reaktivasyon görülürken, 47’ sinde (%73) ilk yılda reaktivasyon görülmüştü. TNFi kullanım süreleri ile reaktivasyon arasındaki ilişki incelendiğinde RA hastalarında TNFi kullanım süresi arttıkça reaktivasyona kadar geçen sürenin azalmış olduğu görüldü (p We aimed to observe the course of individuals with diagnosis of inflammatory rheumatic diseases (IRD) whose remission had been maintained with TNF-α inhibitor (TNFi) therapy, and medication had been suspended. Patients were assessed retrospectively. Patients were assessed with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and disease activity index. Sixty four patients with IRD (22 Rheumatoid Arthritis (RA), 37 Ankylosing Spondylitis (AS), 5 Psoriatic Arthritis (PsA)) were included in our study. Reactivation had been occurred in 58 patients after the cessation of TNFi. The average period until the reactivation was 6 months. Reactivation had been observed in the first year in 47 patients (73%) whereas it occurred in 28 patients (46%) in the first 6 months. Reactivation occurred in the majority of the patients with the cessation of TNFi medication. When the correlation between the TNFi medication periods and the reactivation has been evaluated, it was seen that the time until the reactivation was reduced when the duration of TNFi usage period had been prolonged (p |
| Databáze: | OpenAIRE |
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