Differential Effect of Glutathione Depletion on Glycogenolysis in Isolated Rat Hepatocytes Mediated by a-Adrenoceptor Agonists and Glucagon

Autor:	ATMACA, Mukadder, FRY, Jeffrey R.
Jazyk:	turečtina
Rok vydání:	2014
Předmět:	a-adrenoceptors glucagon glutathione glycogenolysis hepatocytes receptors
Zdroj:	Volume: 35, Issue: 2 71-74 Turkish Journal of Medical Sciences
ISSN:	1300-0144 1303-6165
Popis:	Glutathione (GSH) exerts a variety of cytoprotecive effects, but is readily depleted from cells under a variety of stressful stimuli. The impact of GSH depletion on receptor-mediated activity in rat hepatocytes has been studied with regard to glycogenolysis stimulated with a-adrenoceptor agonists or glucagon, which exert their actions through different signalling pathways. Depletion of GSH content (70%) by diethyl maleate had no effect on the redox status of the cells or on basal or glucagon-stimulated glycogenolysis, but significantly reduced the response to the a-adrenoceptor agonists adrenalin and phenylephrine. These results highlight the possible modulatory effects of GSH on receptor-mediated activity in hepatocytes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=tubitakulakb::83777e225f58a4ed0e8a811fc5eb135c https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12341/147904 Zobrazit plný text záznamu