Apophysomyces elegans Caused Rhino-Orbito Mucormycosis: An Emerging Infection in Immunocompetent Individuals
| Autor: | Singh, N. Dhaneshwor, Sharma, Nishi, Dawa, Lobzang, Malhotra, Shalini |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Volume: 07, Issue: 04 207-212 Journal of Microbiology and Infectious Diseases |
| ISSN: | 2146-3158 2146-9369 |
| Popis: | Mucormycosis is a rarenecrotizing angioinvasive infection caused by fungi of the class Zygomycetes(order Mucorales). It predominantly occurs in immunocompromised/ predisposedindividuals. Recent surge in its incidence in healthy individuals has emphasizedthe need to reconsider our age-old presumption of 'mucormycosis as a classicalopportunistic infection'. Apophysomyces elegans has emerged as a pathogencausing invasive Rhino-Orbitocerebral Mucormycosis (ROCM), mostly inimmunocompetent individuals. Mostly resistant to commonly used azoles andechinocandins, management of A elegansassociated ROCM solely depends on radical debridement and Amphotericin B.Recent reports of Amphotericin B resistant Aelegans strains is disturbing. Till date only 12 cases of ROCM inimmunocompetent/ otherwise healthy individuals attributable to A elegans has been reported.Our main objective is todelineate the clinical characteristics and treatment outcome ofimmunocompentent/ otherwise healthy individuals suffering from A elegans caused ROCM. We also reportfour new cases of A. elagans caused ROCM.J Microbiol Infect Dis 2017; 7(4):207-212 |
| Databáze: | OpenAIRE |
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