A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness
| Autor: | DALO, Feda, YENER, Fatma Gülgün, ALTUNTAŞ, Ebru, DÖŞLER, Sibel |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Volume: 2, Issue: 47 194-201 Fabad Journal of Pharmaceutical Sciences |
| ISSN: | 1300-4182 2651-4648 |
| Popis: | In this study, it was aimed to develop a topically applicablenanoemulsion (NE) that is expected to have an ameliorating effect inseborrheic dermatitis (SD). The main purpose of the formulation is toeliminate the disease factor, to repair the damage caused by the diseaseon the skin and to smooth the skin appearance by moisturization. Forthis reason, in vitro antimicrobial effect and in vivo effectiveness ofthe formulation were tested. For this aim; essential oils from tea tree,sage, cinnamon, oregano; extracts from Aloe vera, colloidal oatmeal,liquorice; vegetable oils from grape seed and sesame, and honey wereused in a NE formulation. The NEs were prepared by ultrasonicationmethod. Preliminary stability tests were applied to all formulationsand then, pH, conductivity, viscosity, average droplet size,polydispersity index (PDI), and zeta potential measurements weretaken on the selected NEs for 3 months. Finally, the antimicrobialeffect and in vivo effectiveness of the optimum NE were tested. Theaverage droplet size, PDI, and zeta potential value of the optimumformulation (F6P2) were 108.40 ± 0.90 nm, 0.195 ± 0.07, and-21.40 ± 1.45 mV, respectively. As a result, the moisture content ofthe skin increased significantly (p < 0.001), the sebum and rednessvalues significantly decreased (p = 0.008 and 0.001, respectively)and there was no significant change in the pH of the volunteers’ skin.Accordingly, it can be concluded that the optimum NE formulationdeveloped in this study may be beneficial as a supplement for patientswith SD. |
| Databáze: | OpenAIRE |
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