Evaluation of Plasma Protein C Antigen, Protein C Activity and Thrombomodulin Levels in Type 2 Diabetic Patients
| Autor: | ASLAN, Berna, EREN, Nezaket, CİĞERLİ, Şebnem, MÜLDÜR, Fatma, YÜCEL, Nihal |
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| Jazyk: | turečtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Volume: 35, Issue: 5 305-310 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | The imbalance between coagulation and fibrinolysis leads to vascular complications in diabetics. In our study, we have investigated the effects of the protein C-thrombomodulin system as a cause of diabetic vascular complications. Whereas PC-Ag levels were lower, thrombomodulin (TM) levels of diabetics were higher than that of the controls (P < 0.001, P < 0.001 respectively). Furthermore, patients were divided into three groups according to their urinary albumin excretion (UAE). Group 1, 2 and 3 consisted of 27 patients with UAC £ 30 µg/ml, 16 patients with UAC in range 30-140 µg/ml, 3 patients with UAC >140 µg/ml, respectively. Plasma PC-Ag levels were significantly decreased in group 1 and 2 with respect to controls (P < 0.01, P < 0.01). Plasma TM concentrations were significantly increased in group 1, 2 and 3 compared with the control group (P < 0.001, P < 0.01, P < 0.01). Patients were also divided into two groups according to the duration of their illness; patients whose diabetic age < 10 years (Group A) and whose diabetic age > 10 years (Group B). In both groups, PC-Ag levels were lower and TM levels higher than that of the control group (P < 0.01, P < 0.01; P < 0.001, P < 0.001 respectively). There was no significant difference between group A and B in PC-Ag levels (P > 0.50) but a significant difference in TM levels (P < 0.001). |
| Databáze: | OpenAIRE |
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