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Objective: We aimedto evaluate and compare the demographic and histopathological features ofmalignant mesothelioma (MM) cases diagnosed in two different provinces inTurkey.Methods: Thedemographic and histopathological characteristics of MM cases diagnosed atPathology Department, Bozok University School of Medicine, and Private BursaPatonet Laboratory were investigated retrospectively.Results: There were15 cases of MM diagnosed at Bozok University School of Medicine. Six(40%) patientswere female, 9(60%) were male. The age ranged from 40 to 82 (mean=67.6±10.86)years. The anatomic location of 13(86.7%) cases were pleura, 1(6.7%) wasscrotum and 1(6.7%) was omentum.Histopathologically, 12 pleural mesotheliomas showed epithelioid subtypeand 1 showed sarcomatoid subtype. The omental mesothelioma exhibitedepithelioid subtype and scrotal mesothelioma exhibited biphasic subtype. Fivecases were smokers. Two cases had asbestos exposure. Four cases werehousewives, 3 were farmers and 2 were construction workers. All cases were bornand resided in Yozgat. Distribution of cases according to districts are asfollows in a descending order of frequency; Sorgun, Cekerek, Central district,Akdagmadeni, and Kadısehri [5(33.3%), 5(33.3%), 2(13.4%), 2(13.4%), and 1(6.6%)cases, respectively].Therewere 3 patients diagnosed as MM at Private Bursa Patonet Laboratory. 2(66.6%)of these patients were male, 1(33.4%) of was female. The mean age of thepatients was 70.33±7.57 years (range:65-79). All cases were located in thepleura. Histologically, 2 cases were epithelioid subtype, and 1 wasdesmoplastic subtype.Results: In theliterature male/female ratio of MM is 4/1, however this ratio was lower in ourstudy. Similar to the literature, pleura was the most frequent site of MM, andthe most frequent histologic subtype was the epithelioid variant. In Yozgat, MMwas more frequently seen in Sorgun and Cekerek compared to other districts. Inorder to elucidate the causes of this geographical distribution, comprehensiveetiological studies are needed.Keywords:mesothelioma, pleura, epithelioid, sarcomatoid, asbestos, Yozgat |
