The Action of a Calcium Channel Blocker (Verapamil) on Gallbladder Contractions in Humans
| Autor: | KAPICIOĞLU, S., ŞENTÜRK, Ö., BAMBUL, N., İLGÜN, K. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Zdroj: | Volume: 5, Issue: 2 55-57 EASTERN JOURNAL OF MEDICINE |
| ISSN: | 1301-0883 |
| Popis: | Objective: The class of calcium antagonists is consti-tuted by pharmacological agents which inhibit the con-traction evoked by extracellular calcium in depolarizedsmooth muscles. While the inhibiting action of calciumantagonists on the gastrointestinal motility is welldocumented, its action on the biliary tract has not beenextensively studied, despite its potential clinical use-fulness. Therefore we investigated the effect of a cal-cium channel blocker (verapamil) on fasting and post-prandial gallbladder volume in normal subjects.Method: Twenty healthy volunteers participated in thisstudy. The gallbladder volumes were measured usingultrasonography. After the baseline measurement wastaken, the volunteers received 80 mg of verapamil (n:10)or a placebo (n:10) per oral in the morning one h be-fore rescanning. The gallbladder was rescanned in 15min intervals for 60 min. At the end of this period allthe volunteers received a standard liquid test meal (En-sure), and then scans were performed again.Results: The administration of verapamil increased thefasting gallbladder volume to a maximum of 61.2% to74.2% compared to the baseline (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|