The Effect of Peripheral Adropin Application on Hypothalamic Pituitary Adrenal Axis in Rats
| Autor: | GÜLER, Mustafa Can, NACAR, Tuncer, ERASLAN, Ersen, TANYELİ, Ayhan, POLAT, Elif, ÇOMAKLI, Selim |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Volume: 4, Issue: 2 60-75 Turkish Journal of Science |
| ISSN: | 2587-0971 |
| Popis: | Purpose:Hypothalamic pituitary adrenal (HPA) axis has many missions such as responses to stress and inflammatory factors. HPA axis is the primer stress response system. Adropin is a peptid structured hormone coded by energy homeostasis related gene. In this study biochemical, histopathologic and immunohistochemical effects of adropin hormone on HPA axis were examined.Material and Method:Thirty two (32) Wistar Albinomale rats were used in the study. The rats were separated into 4 equal groups (n=8). The control group did not receive any applications; and the sham group was given adropin-dissolvent. Adropin was administered as intraperitoneal to the treatment groups at doses of 4 μg/kg and 40 μg/kg.The study lasted 10 days. On the 11thday, the animals were sacrified, and relevant tissue samples were collected.Findings:While cortisole, adrenaline, noradrenaline and serotonin levels decreased, contrary dopamin levels increased. There were no important changes on melatonin levels. As a consequence of immunohistochemical staining, CRH has shown increase in adropin groups compared to other groups. |
| Databáze: | OpenAIRE |
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