FORMULATION AND DETAILED CHARACTERIZATION OF VORICONAZOLE LOADED IN SITU GELS FOR OCULAR APPLICATION
| Autor: | ÜSTÜNDAĞ OKUR, Neslihan, YOZGATLI, Vildan, ŞENYİĞİT, Zeynep |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Volume: 44, Issue: 1 33-49 Journal of Faculty of Pharmacy of Ankara University |
| ISSN: | 1015-3918 2564-6524 |
| Popis: | Objective: This studywas aimed to prepare, characterize and evaluate in situ gel formulation for asustained ocular delivery of voriconazole. Material and Method: In situ gelswere prepared with three different hydrophilic co-polymers: Poloxamer 188, 407and 388. The formulations were characterized in terms of their clarity, pH,viscosity drug content uniformity and mechanical/rheological properties.Moreover, in vitro drug release and stabilitystudies were performed.Resultand Discussion: The results showed that the optimized in situgel formulation had desired in vitro properties and a good stability over theperiod of 3 months. Texture profile analysis presented that formulationsoffered suitable adhesive and mechanical properties. P2-V formulation exhibitedpseudo-plastic flow and typical gel-type mechanical spectra (G′ > G″) atdifferent frequecy values and at different temperatures. Moreover, allformulations showed a sustained drug release for 24 hours. In conclusion,voriconazole loaded in situ gel could be offered as an encouraging strategy asocular systems for ocular infections treatment. |
| Databáze: | OpenAIRE |
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