Ultrastructural examination of the morphological changes in the rat liver following choleduct ligation

Autor:	Arbak, S., Erbengi, T.
Rok vydání:	2016
Předmět:	Medicine Common bile duct ligation hepatocyte hepatic fibrosis Tıp
Zdroj:	Volume: 5, Issue: 1 14-19 Marmara Medical Journal
ISSN:	1019-1941 1309-9469
Popis:	To investigate the effects of common bile duct ligation in rat liver, 20 female Wistar Albinor rats were divided into 1 control and 4 experimental groups in which common bile ducts were ligated successively for 1, 2, 3 and 4 weeks.Electronmicroscopical investigation showed hepatocyte degeneration and fibrosis. We evaluated those morphological changes as follows : invaginations at hepatocyte nuclei, swollen mitochondria, fingerprint formation of hypertrophied granular endoplasmic reticulum within the hepatocyte cytoplasm, dense collagenous fibers at both the Space of Diss6 and portal triad. We concluded as those ultrastructural changes showed an augmentation with increasing ligation period.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=tubitakulakb::349484c110709fa033696ba2f9f41ba9 https://dergipark.org.tr/tr/pub/marumj/issue/23972/255265 Zobrazit plný text záznamu