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BACKGROUND AND OBJECTIVES: Allelic variants in UMOD the gene coding for uromodulin are associated with rare tubulointerstitial kidney disorders and risk of CKD and hypertension in the general population. The factors associated with uromodulin excretion in the normal population remain largely unknown and were therefore explored in this study. DESIGN SETTING PARTICIPANTS MEASUREMENTS: Urinary uromodulin excretion was measured using a validated ELISA in two population based cohorts that included more than 6500 individuals. The Swiss Kidney Project on Genes in Hypertension study (SKIPOGH) included 817 adults (mean age±SD 45±17 years) who underwent renal ultrasonography and performed a 24 hour urine collection. The Cohorte Lausannoise study included 5706 adults (mean age 53±11 years) with fresh spot morning urine samples. We calculated eGFRs using the CKD Epidemiology Collaboration formula and by 24 hour creatinine clearance. RESULTS: In both studies positive associations were found between uromodulin and urinary sodium chloride and potassium excretion and osmolality. In SKIPOGH 24 hour uromodulin excretion (median 41 [interquartile range 29 57] mg/24 h) was positively associated with kidney length and volume and with creatinine excretion and urine volume. It was negatively associated with age and diabetes. Both spot uromodulin concentration and 24 hour uromodulin excretion were linearly and positively associated (multivariate analyses) with eGFR |
