Intramembrane Cleavage of AMA1 Triggers Toxoplasma to Switch from an Invasive to a Replicative Mode

Autor:	Santos JM, Ferguson DJP, Blackman MJ, Soldati-Favre D
Rok vydání:	2011
Předmět:	parasitic diseases
Zdroj:	SCIENCE
Popis:	Apicomplexan parasites invade host cells and immediately initiate cell division. The extracellular parasite discharges transmembrane proteins onto its surface to mediate motility and invasion. These are shed by intramembrane cleavage a process associated with invasion but otherwise poorly understood. Functional analysis of Toxoplasma rhomboid 4 a surface intramembrane protease by conditional overexpression of a catalytically inactive form produced a profound block in replication. This was completely rescued by expression of the cleaved cytoplasmic tail of Toxoplasma or Plasmodium apical membrane antigen 1 (AMA1). These results reveal an unexpected function for AMA1 in parasite replication and suggest that invasion proteins help to promote parasite switch from an invasive to a replicative mode.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=snsf_p3_pubs::9402636b83bcd6bd8c6f9c1bfaae9e5e http://archive-ouverte.unige.ch/unige:14355 Zobrazit plný text záznamu Plný text ve formátu PDF