| Autor: |
Shnaper S., Desbaillets I., Brown D. A., Murat A., Migliavacca E., Schluep M., Ostermann S., Hamou M. F., Stupp R., Breit S. N., de Tribolet N., Hegi M. E. |
| Rok vydání: |
2009 |
| Zdroj: |
Int J Cancer |
| Popis: |
For patients with brain tumors identification of diagnostic and prognostic markers in easy accessible biological material such as plasma or cerebrospinal fluid (CSF) would greatly facilitate patient management. MIC 1/GDF15 (growth differentiation factor 15) is a secreted protein of the TGF beta superfamily and emerged as a candidate marker exhibiting increasing mRNA expression during malignant progression of glioma. Determination of MIC 1/GDF15 protein levels by ELISA in the CSF of a cohort of 94 patients with intracranial tumors including gliomas meningioma and metastasis revealed significantly increased concentrations in glioblastoma patients (median 229 pg/ml) when compared with control cohort of patients treated for non neoplastic diseases (median below limit of detection of 156 pg/ml p < 0.0001 Mann Whitney test). However plasma MIC 1/GDF15 levels were not elevated in the matching plasma samples from these patients. Most interestingly patients with glioblastoma and increased CSF MIC 1/GDF15 had a shorter survival (p = 0.007 log rank test). In conclusion MIC 1/GDF15 protein measured in the CSF may have diagnostic and prognostic value in patients with intracranial tumors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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