Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression
| Autor: | Piazzon N Bernet F Guihard L Leonhard WN Urfer S Firsov D Chehade H Vogt B Piergiovanni S P |
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| Rok vydání: | 2015 |
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| Zdroj: | J Transl Med |
| Popis: | Background Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by numerous fluid filled cysts that frequently result in end stage renal disease. While promising treatment options are in advanced clinical development early diagnosis and follow up remain a major challenge. We therefore evaluated the diagnostic value of Fetuin A as a new biomarker of ADPKD in human urine. Results We found that renal Fetuin A levels are upregulated in both Pkd1 and Bicc1 mouse models of ADPKD. Measurement by ELISA revealed that urinary Fetuin A levels were significantly higher in 66 ADPKD patients (17.5?±?12.5 µg/mmol creatinine) compared to 17 healthy volunteers (8.5?±?3.8 µg/mmol creatinine) or 50 control patients with renal diseases of other causes (6.2?±?2.9 µg/mmol creatinine). Receiver operating characteristics (ROC) analysis of urinary Fetuin A levels for ADPKD rendered an optimum cut off value of 12.2 µg/mmol creatinine corresponding to 94 of sensitivity and 60 of specificity (area under the curve 0.74 ; p?=?0.0019). Furthermore urinary Fetuin A levels in ADPKD patients correlated with the degree of renal insufficiency and showed a significant increase in patients with preserved renal function followed for two years. Conclusions Our findings establish urinary Fetuin A as a sensitive biomarker of the progression of ADPKD. Further studies are required to examine the pathogenic mechanisms of elevated renal and urinary Fetuin A in ADPKD. |
| Databáze: | OpenAIRE |
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