| Autor: |
Nnamdi, Duru B., Chukwuemeka, Meludu S., Chukwuemeka, Ogbodo E., Ejike, Onah C., Friday, Ehiaghe A., Bridget, Onyema-iloh O., Clement, Amaifeobu, Emmanuel, Mbam R. |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Zdroj: |
INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH; Vol 8 No 01 (2023): International Journal of Applied Pharmaceutical Sciences and Research; 1-7 |
| ISSN: |
2455-8095 |
| Popis: |
This longitudinal study assessed the patterns of immunoglobulin G and M levels in HIV serodiscordant couples. A total of20 serodiscordant HIV couples (40 patients) and 20 controls (40 HIV seronegative couples) were randomly recruited forthe study. Five milliliters of venous blood samples were collected from each of the participants at baseline, after 6 months,and after 12 months follow up period respectively for the determination of Immunoglobulin G (IgG) and ImmunoglobulinM (IgM) levels using immunoturbidimetric method. Results showed thatthere was a statistically significant decrease in themean serum level of IgG in the HIV discordant test group at baseline and 6 months than in the control group (p=0.000)but remained similar after 12 months follow up (p=0.081). The mean serum IgM level observed in the HIV discordant testgroup did not differ significantly (p>0.05) compared to the control group at baseline, after 6 months, and 12 months followup respectively. The mean serum levels of IgG was significantly decreased in the male test group compared to male controlsat baseline and 6 months but were similar at 12 months whereas there were no significant differences observed inserum levels of IgG in the female test groups at baseline, 6 months and 12 months follow up respectively. Furthermore, themean serum IgM levels in both the male and female test groups did not differ significantly at baseline and after 6 monthsfollow up compared with the male and female control group respectively. However, the mean serum IgM levels in the maletest group was significantly decreased after 12 months follow up compared with the male control group. Therefore, HIVserodiscordance status may influence the serum IgG and IgM levels in affected individuals. Further studies are necessaryto unravel the mechanism behind these findings. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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