| Autor: |
Badri, Sana, Carella, Beth, Lhoumaud, Priscillia, Castro, Dayanne M., Raviram, Ramya, Watters, Aaron, Bonneau, Richard, Skok, Jane A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| DOI: |
10.1101/654418 |
| Popis: |
CRLF2 overexpression in B-ALL patients with an IGH-CRLF2 translocation activates JAK-STAT, PI3K and ERK/MAPK signaling pathways. Although inhibitors of these pathways are available, investigating alternate targets could reduce treatment-associated toxicities. Comparing RNA-seq from IGH-CRLF2 and non-translocated patients we defined a translocation gene signature. Next, we assembled a B-ALL cancer-specific regulatory network using 529 B-ALL patient samples from the NCI TARGET database coupled with priors generated from ATAC-seq peak TF-motif analysis. The network was used to infer differential changes in TF activities predicted to control IGH-CRLF2 deregulated genes, thereby enabling identification of translocation-associated pathways and potential new therapeutic targets. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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