| Autor: |
Rau, Christoph D., Gonzales, Natalia M., Park, Danny, Palmer, Abraham A., Lusis, Aldons J., Zaitlen, Noah |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| DOI: |
10.1101/555383 |
| Popis: |
Background Commonly used genetic models of phenotype assume that alleles have similar effects in all individuals. Mounting evidence suggests that higher-order interactions, which may vary between populations, profoundly affect phenotypic variation. The effect of genetic and environmental perturbations may therefore differ across genetic backgrounds. In this manuscript, we develop a statistical test that determines whether the effect of a mutation on a complex phenotype changes as a function of ancestral background. Results We apply our test to two large cohorts of mice and observe 49 significant gene by ancestry interaction associations across 14 phenotypes as well as over 1,400 Bonferroni-corrected gene by ancestry interaction associations in gene expression data. We also observe evidence of rapid selection pressure on individual polymorphisms within one of the cohorts. Conclusions Unlike our prior work in human populations, we observe widespread evidence of ancestry-specific SNP effects, perhaps reflecting the greater divergence present in crosses among laboratory mice. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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