| Autor: |
Lavalou, J., Mao, Q., Harmansa, S., Kerridge, S., Lellouch, A. C., Philippe, J.-M., Audebert, S., Camoin, L., Lecuit, T. |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| DOI: |
10.1101/2020.03.16.993758 |
| Popis: |
During development, interfaces between cells with distinct genetic identities generate signals organizing local cell behaviors to drive tissue morphogenesis. During Drosophila embryonic axis extension, stripes of pair rule genes position parasegment boundaries and orchestrate polarized cell intercalation driven by planar polarized Myosin-II via patterned expression of several Toll receptors. However, how Toll receptors define polarized contractile interfaces remains unknown. Here we show that differential expression of Toll-8 polarizes Myosin-II through a physical interaction with the adhesion GPCR Cirl/Latrophilin. We report that Toll-8 activates Myosin-II by inducing Cirl asymmetric localization at the boundary of its expression domain. Cirl asymmetry is in turn sufficient to activate Myosin-II. Toll-8 and Cirl exhibit dynamic interdependent interactions to yield robust planar polarity when neighboring cells express different levels of Toll-8. This reveals how planar polarized signaling arises from a scalar gradient of a single Toll receptor interpreted through self-organized feedbacks with a GPCR. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
