| Autor: |
Ariza, Juan Manuel, Döpfer, Dörte, Anklam, Kelly, Labrut, Sophie, Oberle, Kenny, Bareille, Nathalie, Relun, Anne, Guatteo, Raphaël |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| DOI: |
10.1101/2019.12.20.882787 |
| Popis: |
Bovine digital dermatitis (DD), is a highly prevalent disease among dairy cattle characterized by ulcerative and painful lesions. While multiple risk factors are involved in the disease, its precise etiology remains unclear and the effectiveness of the current control strategies still highly variable. However, and even if the main role of Treponema spp. in the development of the disease is consistently recognized, the importance of other bacterial communities and the factors affecting the skin environment remains uncertain. The objective of this study was to investigate the dynamics of microbiotas from feet affected by DD, before and after the implementation of disinfectant footbaths under field conditions. During this investigation, the diversity, structure, and composition of microbiotas from DD lesions over time were explored according to different clinical factors. The findings of this investigation confirmed a particular microbiota related to DD lesions dominated by Treponema spp. and highly different from those microbiotas of healthy skin. However, the diversity and structure of microbiotas from DD lesions did not vary according to the usage of footbaths or individual topical antibiotic treatments. Otherwise, microbiotas from proliferative lesions evidenced a different structure and diversity in comparison to non-proliferative lesions. The composition of microbiotas changed over time revealing the potential main role of Treponema spp. , Fusobacterium spp. , Mycoplasma spp. and Porphyromonas spp. in the dynamics of DD lesion progression. Further studies are necessaries to confirm if the clinical evolution of DD lesions is driven by a particular microbiota and how this microbiota induces disease. Highlights Multiple bacteria have been identified in DD lesions. However, a large part of these microorganisms are inhabitants of the foot skin and the farm environment. For the first time, the microbiotas of DD lesions were followed over 45 days under field conditions to explore their evolution over time and how footbaths practices may affect their dynamics. The results of this investigation confirmed a particular microbiota related to DD lesions dominated by Treponema spp. and highly different from those microbiotas of healthy skin. The microbiotas from DD lesions evolved over the study period and the differential bacteria were identified. Further studies are guaranteed to determine the role of the bacteria composing these microbiotas on the lesion occurrence and its outcome. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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