| Autor: |
Johnson, Corbin S.C., Shively, Carol A., Michalson, Kristofer T., Lea, Amanda J., DeBo, Ryne J., Howard, Timothy D., Hawkins, Gregory A., Appt, Susan E., Liu, Yongmei, McCall, Charles E., Herrington, David, Register, Thomas C., Snyder-Mackler, Noah |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| DOI: |
10.1101/2020.01.27.917567 |
| Popis: |
Summary Monocytes and macrophages—important mediators of innate immunity, health, and disease—are sensitive to diet and stress. Western diets promote inflammation and disease, while Mediterranean diets reduce inflammation and promote health, although the mechanisms through which diet alters immune function are unknown. Here, we conducted the first randomized, long-term diet trial in which macaques were fed either a Western- or Mediterranean-like diet to determine how diet and behavior interact to influence monocyte polarization–a precursor to subsequent health outcomes. Monocyte gene expression profiles differed markedly between the two diets, with over 40% of expressed genes being differentially expressed (FDR |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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