| Autor: |
Winkel, Frederike, Voigt, Mathias B., Didio, Giuliano, Matéo, Salomé, Jetsonen, Elias, Pou, Maria Llach, Steinzeig, Anna, Ryazantseva, Maria, Harkki, Juliana, Englund, Jonas, Khirug, Stanislav, Rivera, Claudio, Palva, Satu, Taira, Tomi, Lauri, Sari E., Umemori, Juzoh, Castrén, Eero |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| DOI: |
10.1101/2020.04.27.063503 |
| Popis: |
Summary Critical period plasticity during early postnatal life is followed by a consolidated state through the maturation of interneuron networks and development of perineuronal nets (PNN) surrounding parvalbumin (PV) interneurons. However, critical period-like plasticity can be induced in the adult brain (iPlasticity). Over a shorter time scale, PV interneurons can alternate between high and low plasticity states (PV-plasticity) to regulate memory encoding and consolidation. We now show that iPlasticity and PV-plasticity in the adult visual cortex are induced by the activation of TrkB neurotrophin receptors in PV interneurons. Optical activation of TrkB specifically in PV interneurons switches adult cortical networks into a state of elevated plasticity within minutes. The activation changes PV properties characterized by ocular dominance plasticity and reduced PV and PNN expression. Our results show that TrkB activity within PV interneurons is essential for iPlasticity and orchestrates plasticity states within adult cortical networks. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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