| Autor: |
Lam, Su Datt, Bordin, Nicola, Waman, Vaishali P, Scholes, Harry M, Ashford, Paul, Sen, Neeladri, van Dorp, Lucy, Rauer, Clemens, Dawson, Natalie L, Pang, Camilla SM, Abbasian, Mahnaz, Sillitoe, Ian, Edwards, Sarah JL, Fraternali, Franca, Lees, Jonathan G, Santini, Joanne M, Orengo, Christine A |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| DOI: |
10.1101/2020.05.01.072371 |
| Popis: |
SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals. To enter host cells, the viral spike protein (S-protein) binds to its receptor, ACE2, and is then processed by TMPRSS2. Whilst receptor binding contributes to the viral host range, S-protein:ACE2 complexes from other animals have not been investigated widely. To predict infection risks, we modelled S-protein:ACE2 complexes from 215 vertebrate species, calculated their relative energies, correlated these energies to COVID-19 infection data, and analysed structural interactions. We predict that known mutations are more detrimental in ACE2 than TMPRSS2. Finally, we demonstrate phylogenetically that human SARS-CoV-2 strains have been isolated in animals. Our results suggest that SARS-CoV-2 can infect a broad range of mammals, but not fish, birds or reptiles. Susceptible animals could serve as reservoirs of the virus, necessitating careful ongoing animal management and surveillance. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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