| Autor: |
Yang, Sujeong, Gigout, Sylvain, Molinaro, Angelo, Naito-Matsui, Yuko, Hilton, Sam, Foscarin, Simona, Nieuwenhuis, Bart, Verhaagen, Joost, Pizzorusso, Tommaso, Saksida, Lisa M., Bussey, Timothy M., Kitagawa, Hiroshi, Kwok, Jessica C.F., Fawcett, James W. |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| DOI: |
10.1101/2020.01.03.894188 |
| Popis: |
Memory loss is a usual consequence of ageing. In aged brains, perineuronal nets (PNNs), which limit neuroplasticity and are implicated in memory, become inhibitory due to decreased 6-sulphation of their glycan chains (C6S). Aged mice show progressive deficits in memory tasks, but removal of PNNs or digestion of their glycans rescued age-related memory loss. Reduction of permissive C6S by transgenic deletion of 6-sulfotransferase led to very early memory loss. However, restoring C6S levels in aged animals by AAV delivery or transgenic expression of 6-sulfotransferase restored memory. Low C6S levels caused loss of cortical long-term potentiation, which was restored by AAV-mediated 6-sulfotransferase delivery. The study shows that loss of C6S in the aged brain leads to declining memory and cognition, which can be restored by C6S replacement. One sentence summary Sulphation changes in perineuronal nets lead to age-related memory loss; correction of sulphation restores memory. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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