| Autor: |
Jayaprakash, Anitha D., Ronk, Adam J., Prasad, Abhishek N., Covington, Michael F., Stein, Kathryn R., Schwarz, Toni M., Hekmaty, Saboor, Fenton, Karla A., Geisbert, Thomas W, Basler, Christopher F., Bukreyev, Alexander, Sachidanandam, Ravi |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| DOI: |
10.1101/2020.04.13.039503 |
| Popis: |
The filoviruses Ebola (EBOV) and Marburg (MARV) cause severe disease in humans. In contrast, the Egyptian rousette bat ( Rousettus aegyptiacus ), a natural reservoir of MARV, exhibits a subclinical phenotype with limited MARV replication and nearly undetectable EBOV replication. Rousettus cell lines support replication of filoviruses, however. To understand the bat-filovirus interaction, transcriptomes of tissues from EBOV- and MARV-infected R. aegyptiacus bats were analyzed. While viral transcripts were only detected in liver, a systemic response was observed involving other tissues as well. By focusing on evolutionarily divergent (from human homologues) protein-coding genes, we identified novel transcriptional pathways that suggest infected bats exhibit impaired coagulation, vasodilation, aberrant iron regulation, and impaired complement system leading to muted antibody responses. Furthermore, a robust T-cell response and an anti-inflammatory state driven by M2 macrophages were identified. These processes likely control infection and limit pathology. All data can be freely explored and downloaded through our tools ( http://katahdin.girihlet.com/shiny/bat/ ). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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