| Autor: |
Dondas, H. Ali, Hempshall, Aiden, Narramore, Sarah, Kilner, Colin, Fishwick, Colin W. G., Grigg, Ronald |
| Rok vydání: |
2016 |
| Popis: |
gamma-Carbolines were prepared from pyrido[4,3-b]-5H-indoles via Pd(0)-catalysed, stereo and regioselective allene/uridine allene insertion 3- and 5-component cascades. This versatile reaction sequence gives a range of structurally diverse carboline derivatives and tolerates a broad range of substrates. The power of this approach has been harnessed to produce gamma-carboline based HDAC inhibitors. (C) 2016 Elsevier Ltd. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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