| Autor: |
Bastaskin, Tugce, Kaya, Ecem, Ozakca, Isil, Yilmaz, Didem, Bayatli, Nur, Akdemir, Alp Ozgur, Gur, Serap |
| Rok vydání: |
2017 |
| Předmět: |
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| Popis: |
Aim: We investigated the effects of silodosin (selective (1A)-adrenoceptor antagonist) on erectile dysfunction (ED) in a rat model of bladder outlet obstruction.Methods: Adult male Sprague-Dawley rats (n=32) were divided into four groups: (i) sham-operated control; (ii) silodosin-treated (sham) control (0.1mg/kg/day); (iii) partial bladder outlet obstruction (PBOO); and (iv) silodosin-treated with PBOO. PBOO was induced by ligation of the urethra for 6 weeks. In vivo, erectile responses were monitored by evaluating ratios of intracavernosal pressure (ICP)/mean arterial pressure (MAP). Organ-bath studies were performed on corpus cavernosum (CC) strips. Penises were assessed at baseline for protein expression of neuronal nitric oxide synthase (nNOS) and Rho-associated protein kinase (ROCK2) by Western blot. Immunohistochemistry and Masson trichrome staining were performed for analysis of nNOS protein levels and tissue alterations.Results: The ratio of ICP/MAP was significantly decreased in obstructed rats (0.260.043, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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